Author's response to reviews Title: Molecular differential diagnosis of follicular thyroid carcinoma and adenoma based on gene expression profiling by using formalin-fixed paraffin-embedded tissues Authors:
نویسندگان
چکیده
Aleksandra Pfeifer ([email protected]) Bartosz Wojtas ([email protected]) Malgorzata Oczko-Wojciechowska ([email protected]) Aleksandra Kukulska ([email protected]) Agnieszka Czarniecka ([email protected]) Markus Eszlinger ([email protected]) Thomas Musholt ([email protected]) Tomasz Stokowy ([email protected]) Michal Swierniak ([email protected]) Ewa Stobiecka ([email protected]) Dagmara Rusinek ([email protected]) Tomasz Tyszkiewicz ([email protected]) Monika Kowal ([email protected]) Michal Jarzab ([email protected]) Steffen Hauptmann ([email protected]) Dariusz Lange ([email protected]) Ralf Paschke ([email protected]) Barbara Jarzab ([email protected])
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Detection of Survivin Gene Expression in Formalin-Fixed Paraffin-Embedded Tissues of Human Osteosarcoma: Its Potential Usefulness in Diagnosis and Prognosis of Bone Tumors
Osteosarcoma is a relatively uncommon malignancy however, it is the most common form of primary malignant bone tumors in human. Diagnosis and prognosis of patients with osteosarcoma is limited to clinico-radiopathological parameters, whereas molecular markers of tumor aggression have been poorly identified. Survivin, an inhibitor of apoptosis (IAP), is unique for its expression in human tumors ...
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Distinguishing between follicular thyroid cancer (FTC) and follicular thyroid adenoma (FTA) constitutes a long-standing diagnostic problem resulting in equivocal histopathological diagnoses. There is therefore a need for additional molecular markers. To identify molecular differences between FTC and FTA, we analyzed the gene expression microarray data of 52 follicular neoplasms. We also perform...
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OBJECTIVE To see the expression of cytokeratin 19, a proven helpful marker for the differential diagnosis of neoplastic follicular patterned lesions of thyroid. METHODS This was a retrospective study carried out in the Department of Pathology, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi from 2000 to 2005. The haematoxylin and eosin (H&E) stained sections were...
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OBJECTIVES To characterize trefoil factor 3 (TFF3) expression in normal thyroid tissue samples compared with that in follicular adenoma, follicular carcinoma, and follicular variant of papillary thyroid carcinoma using immunohistochemistry on tissue microarrays. DESIGN Immunohistochemical analysis of 83 normal thyroid tissue and of 83 follicular neoplasms (26 follicular adenomas, 25 follicula...
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